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Direct Functionalization of Alkyl Ethers to Construct Hemiaminal Ether Skeletons (HESs)

Abstract

Hemiaminal ether skeletons (HESs) are important backbones generally existed in organic compounds. Compared to the traditional functional group transformations, strategies for C-H functionalization of alkyl ethers to construct the HESs have drawn much attention in the past decade. In this review, we focus on the recent progresses in developing various pathways to construct HESs via direct functionalization of alkyl ethers, including: a) the transition-metal catalyzed nitrene insertion pathway; b) the transition-metal-free organonitrenoid insertion pathway; c) the transition-metal-catalyzed cross-coupling process, and d) the radical involved cross-coupling pathways under metal-free conditions.

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Publication details

The article was received on 04 Apr 2018, accepted on 01 May 2018 and first published on 02 May 2018


Article type: Review Article
DOI: 10.1039/C8OB00793D
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Direct Functionalization of Alkyl Ethers to Construct Hemiaminal Ether Skeletons (HESs)

    Y. Du, L. Dian, Q. Xing and D. Zhang-Negrerie, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB00793D

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