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Issue 24, 2018
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Direct functionalization of alkyl ethers to construct hemiaminal ether skeletons (HESs)

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Abstract

Hemiaminal ether skeletons (HESs) are important backbones generally found in organic compounds. Compared to traditional functional group transformations, strategies for the C–H functionalization of alkyl ethers to construct HESs have drawn much attention in the past decade. In this review, we focus on the recent progress in developing various pathways to construct HESs via the direct functionalization of alkyl ethers, including: (a) the transition-metal-catalyzed nitrene insertion pathway, (b) the transition-metal-free organonitrenoid insertion pathway, (c) the transition-metal-catalyzed cross-coupling process and (d) the radical-involved cross-coupling pathway under metal-free conditions.

Graphical abstract: Direct functionalization of alkyl ethers to construct hemiaminal ether skeletons (HESs)

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Publication details

The article was received on 04 Apr 2018, accepted on 01 May 2018 and first published on 02 May 2018


Article type: Review Article
DOI: 10.1039/C8OB00793D
Citation: Org. Biomol. Chem., 2018,16, 4384-4398
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    Direct functionalization of alkyl ethers to construct hemiaminal ether skeletons (HESs)

    L. Dian, Q. Xing, D. Zhang-Negrerie and Y. Du, Org. Biomol. Chem., 2018, 16, 4384
    DOI: 10.1039/C8OB00793D

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