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Issue 17, 2018
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A convergent formal [4 + 2] cycloaddition of 1,6-diynes and benzyl azides: construction of spiro-polyheterocycles

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Abstract

A convergent formal [4 + 2] cycloaddition reaction for the construction of structurally appealing spiro-tetrahydroquinolines has been developed, in which, a one-pot reaction is established for the in situ generation of two reagents, a cyclic alkyne and an N-aryliminium ion, from the corresponding precursors in the presence of an Au-catalyst and Brønsted acid, respectively.

Graphical abstract: A convergent formal [4 + 2] cycloaddition of 1,6-diynes and benzyl azides: construction of spiro-polyheterocycles

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Publication details

The article was received on 28 Mar 2018, accepted on 04 Apr 2018 and first published on 04 Apr 2018


Article type: Paper
DOI: 10.1039/C8OB00735G
Citation: Org. Biomol. Chem., 2018,16, 3258-3265
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    A convergent formal [4 + 2] cycloaddition of 1,6-diynes and benzyl azides: construction of spiro-polyheterocycles

    M. Bao, W. Lu, H. Su, L. Qiu and X. Xu, Org. Biomol. Chem., 2018, 16, 3258
    DOI: 10.1039/C8OB00735G

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