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Issue 17, 2018
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A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cells

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Abstract

Nitroreductase and acidity are common features of a tumor, which is associated with serious disease with a high mortality rate. However, solo detection of nitroreductase or acidic environments may cause false-positive results. Thus, it is very meaningful to develop dual functional probes for detecting nitroreductase and acidity, as these could be used for accurate tumor imaging. Here we report on the first dual functional ratiometric fluorescent probe, NAFP, for acidity and nitroreductase detection. This probe enables the measurement of the acidic microenvironment and the concentration of nitroreductase at the same time and the same site. The probe can obviously distinguish acidity, nitroreductase, and nitroreductase in an acidic environment. Furthermore, confocal fluorescence imaging of A549 cells indicates that NAFP can detect acidity and expressed nitroreductase in living cells.

Graphical abstract: A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cells

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Publication details

The article was received on 19 Mar 2018, accepted on 29 Mar 2018 and first published on 29 Mar 2018


Article type: Paper
DOI: 10.1039/C8OB00670A
Citation: Org. Biomol. Chem., 2018,16, 3266-3272
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    A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cells

    Z. He, Y. Chou, H. Zhou, H. Zhang, T. Cheng and G. Liu, Org. Biomol. Chem., 2018, 16, 3266
    DOI: 10.1039/C8OB00670A

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