Jump to main content
Jump to site search

Issue 22, 2018
Previous Article Next Article

Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum

Author affiliations

Abstract

Two new 6-norpolycyclic polyprenylated acylphloroglucinols (PPAPs), hypermonins A (1) and B (2), featuring an undescribed decahydroindeno[1,7-bc]furan ring system, were isolated from the leaves and twigs of Hypericum monogynum. These compounds are a pair of epimers with opposite configurations at the C-5 position. Their structures, including their absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway of 1 and 2 was also proposed. Compound 1 exhibited a significant protective effect against corticosterone-induced injury in PC12 cells.

Graphical abstract: Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Mar 2018, accepted on 14 May 2018 and first published on 17 May 2018


Article type: Paper
DOI: 10.1039/C8OB00650D
Citation: Org. Biomol. Chem., 2018,16, 4195-4198
  •   Request permissions

    Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum

    Y. Zeng, P. Yi, W. Gu, C. Xiao, L. Huang, D. Tian, H. Yan, D. Chen, C. Yuan and X. Hao, Org. Biomol. Chem., 2018, 16, 4195
    DOI: 10.1039/C8OB00650D

Search articles by author

Spotlight

Advertisements