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Issue 17, 2018
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2,3-Diaroyl benzofurans from arynes: sequential synthesis of 2-aroyl benzofurans followed by benzoylation

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Abstract

A cascade synthetic strategy for the direct synthesis of 2-aroyl benzofurans from aryne precursors has been developed. This reaction proceeds via C–O and C–C bond cleavage as well as C–O and C–C bond formation in a single reaction vessel. The methodology provides good yields of 2-aroyl benzofurans and tolerates a variety of functional groups. The synthesized 2-aroyl benzofurans were further benzoylated at 3-positions and one of the synthesized 2,3-diaroyl benzofuran structures was confirmed unambiguously by X-ray crystallography.

Graphical abstract: 2,3-Diaroyl benzofurans from arynes: sequential synthesis of 2-aroyl benzofurans followed by benzoylation

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Publication details

The article was received on 14 Mar 2018, accepted on 31 Mar 2018 and first published on 04 Apr 2018


Article type: Paper
DOI: 10.1039/C8OB00631H
Citation: Org. Biomol. Chem., 2018,16, 3138-3150
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    2,3-Diaroyl benzofurans from arynes: sequential synthesis of 2-aroyl benzofurans followed by benzoylation

    K. Neog, B. Das and P. Gogoi, Org. Biomol. Chem., 2018, 16, 3138
    DOI: 10.1039/C8OB00631H

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