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A concise total synthesis of cochlearoid B

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Abstract

A T-type calcium channel inhibiting natural product cochlearoid B was synthesized for the first time in 7 linear steps via a convergent strategy exploiting the Suzuki–Miyaura cross coupling and the acid promoted Prins cyclization cascade. This strategy allows rapid access to its structural analogues for further therapeutical development.

Graphical abstract: A concise total synthesis of cochlearoid B

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Publication details

The article was received on 12 Mar 2018, accepted on 05 Apr 2018 and first published on 10 Apr 2018


Article type: Communication
DOI: 10.1039/C8OB00615F
Citation: Org. Biomol. Chem., 2018, Advance Article
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    A concise total synthesis of cochlearoid B

    W. Zhang, D. Xiao and B. Wang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00615F

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