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Binding-promoted chemical reaction in the nanospace of a binding site: effects of environmental constriction

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Abstract

Chemical reactions in a confined nanospace can be very different from those in solution. Imine formation between molecular amines and an aldehyde inside a molecularly imprinted receptor was promoted strongly by the binding. Although how well the amine fit in the binding pocket and its electronic nature both influenced the reaction, the freedom of movement for the amine was the most important factor determining the binding-normalized reactivity.

Graphical abstract: Binding-promoted chemical reaction in the nanospace of a binding site: effects of environmental constriction

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Publication details

The article was received on 08 Mar 2018, accepted on 02 Apr 2018 and first published on 03 Apr 2018


Article type: Communication
DOI: 10.1039/C8OB00590G
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Binding-promoted chemical reaction in the nanospace of a binding site: effects of environmental constriction

    X. Xing and Y. Zhao, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00590G

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