Jump to main content
Jump to site search

Issue 17, 2018
Previous Article Next Article

An unprecedented tandem synthesis of fluorescent coumarin-fused pyrimidines via copper-catalyzed cross-dehydrogenative C(sp3)–N bond coupling

Author affiliations

Abstract

An efficient, one-pot Cu-catalyzed tandem synthesis of fluorescent 1-benzyl-2-phenyl-1,2-dihydro-5H-chromeno[4,3-d]pyrimidin-5-ones from 4-chloro-3-formylcoumarin and benzylamines was developed by in situ intramolecular cross-dehydrogenative C(sp3)–N bond formation in moderate-to-good yields under ligand-free ambient conditions. This synthesis was easily scalable, and the generality of the substrates was established. These coumarin-fused pyrimidines exhibited interesting photo-physical properties and high quantum yields, and would be potential candidates for facilitating suitable studies in medicinal chemistry and materials science.

Graphical abstract: An unprecedented tandem synthesis of fluorescent coumarin-fused pyrimidines via copper-catalyzed cross-dehydrogenative C(sp3)–N bond coupling

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Mar 2018, accepted on 05 Apr 2018 and first published on 05 Apr 2018


Article type: Paper
DOI: 10.1039/C8OB00586A
Citation: Org. Biomol. Chem., 2018,16, 3220-3228
  •   Request permissions

    An unprecedented tandem synthesis of fluorescent coumarin-fused pyrimidines via copper-catalyzed cross-dehydrogenative C(sp3)–N bond coupling

    S. Kumari, S. M. A. Shakoor, S. Khullar, S. K. Mandal and R. Sakhuja, Org. Biomol. Chem., 2018, 16, 3220
    DOI: 10.1039/C8OB00586A

Search articles by author

Spotlight

Advertisements