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Enantioselective amination of nitroolefins under base-free and water-rich conditions using chiral bifunctional phase-transfer catalysts

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Abstract

The direct enantioselective amination of nitroolefins has been performed with L-tert-leucine-derived squaramide-scaffold bifunctional phase-transfer catalysts under base-free and water-rich conditions with low catalyst loading (0.5–1 mol%) to provide 2-aminonitroalkanes in good yields (up to 96%) and enantioselectivities (up to 93% ee).

Graphical abstract: Enantioselective amination of nitroolefins under base-free and water-rich conditions using chiral bifunctional phase-transfer catalysts

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Publication details

The article was received on 08 Mar 2018, accepted on 27 Mar 2018 and first published on 28 Mar 2018


Article type: Paper
DOI: 10.1039/C8OB00583D
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Enantioselective amination of nitroolefins under base-free and water-rich conditions using chiral bifunctional phase-transfer catalysts

    J. Zhu, D. Cui, Y. Li, J. He, W. Chen and P. Wang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00583D

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