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Issue 15, 2018
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Metal-free α-alkylation of alcohols with para-quinone methides

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Abstract

A metal-free α-alkylation of alcohols with para-quinone methides (p-QMs) for accessing alcohol-containing phenols and dihydroisocoumarins has been developed. The alcohols were converted to α-oxy radicals in the presence of di-tert-butyl peroxide (DTBP), which were added to p-QMs for aromatization and C(sp3)–C(sp3) bond formation.

Graphical abstract: Metal-free α-alkylation of alcohols with para-quinone methides

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Publication details

The article was received on 07 Mar 2018, accepted on 14 Mar 2018 and first published on 16 Mar 2018


Article type: Paper
DOI: 10.1039/C8OB00568K
Citation: Org. Biomol. Chem., 2018,16, 2762-2767
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    Metal-free α-alkylation of alcohols with para-quinone methides

    J. Qi, Z. Deng, B. Huang and S. Cui, Org. Biomol. Chem., 2018, 16, 2762
    DOI: 10.1039/C8OB00568K

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