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Issue 16, 2018
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Ruthenium(II)-catalyzed remote C–H addition of 8 aminoquinoline amide to activated aldehyde

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Abstract

Ruthenium(II)-catalyzed regioselective remote C–H addition of 8-aminoquinoline amides at C-5 position to ethyl glyoxalate and 2,2,2-trifluoroacetaldehyde have been developed. The transformation affords C-5 functionalized quinolines in moderate to good yields. This method is applicable to various aryl, heteroaryl as well as aliphatic carboxamides. Experimental results suggest that the reaction very likely proceeds through an ionic pathway.

Graphical abstract: Ruthenium(ii)-catalyzed remote C–H addition of 8 aminoquinoline amide to activated aldehyde

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Publication details

The article was received on 03 Mar 2018, accepted on 24 Mar 2018 and first published on 26 Mar 2018


Article type: Communication
DOI: 10.1039/C8OB00537K
Citation: Org. Biomol. Chem., 2018,16, 2846-2850
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    Ruthenium(II)-catalyzed remote C–H addition of 8 aminoquinoline amide to activated aldehyde

    S. Mondal and A. Hajra, Org. Biomol. Chem., 2018, 16, 2846
    DOI: 10.1039/C8OB00537K

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