Jump to main content
Jump to site search

Issue 14, 2018
Previous Article Next Article

Stereoselective preparation of key intermediates for the synthesis of iso-, neuro- and phyto-prostane family members: inaugural asymmetric synthesis of 17-E2c-dihomo- and 17-F2c-dihomo-isoprostanes

Author affiliations

Abstract

A practical methodology for the synthesis of key intermediates for isoprostane, neuroprostane and dihomo-isoprostane preparation has been described. The key strategy involved a three stage C-12 stereocenter inversion of the configuration of a Corey lactone, commercially available in an enantiopure form. The key intermediate was then used to prepare 17-E2c-dihomo-isoprostane and 17-F2c-dihomo-isoprostane.

Graphical abstract: Stereoselective preparation of key intermediates for the synthesis of iso-, neuro- and phyto-prostane family members: inaugural asymmetric synthesis of 17-E2c-dihomo- and 17-F2c-dihomo-isoprostanes

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Feb 2018, accepted on 10 Mar 2018 and first published on 13 Mar 2018


Article type: Communication
DOI: 10.1039/C8OB00489G
Citation: Org. Biomol. Chem., 2018,16, 2393-2396
  •   Request permissions

    Stereoselective preparation of key intermediates for the synthesis of iso-, neuro- and phyto-prostane family members: inaugural asymmetric synthesis of 17-E2c-dihomo- and 17-F2c-dihomo-isoprostanes

    A. Gandini, A. A. Amin, H. I. M. Amin, D. Corriero, A. Porta and G. Zanoni, Org. Biomol. Chem., 2018, 16, 2393
    DOI: 10.1039/C8OB00489G

Search articles by author

Spotlight

Advertisements