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Issue 17, 2018
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Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters via C–N bond activation

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Abstract

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C–N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.

Graphical abstract: Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters via C–N bond activation

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Publication details

The article was received on 27 Feb 2018, accepted on 03 Apr 2018 and first published on 04 Apr 2018


Article type: Communication
DOI: 10.1039/C8OB00488A
Citation: Org. Biomol. Chem., 2018,16, 3099-3103
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    Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters via C–N bond activation

    W. Yu, S. Yang, F. Xiong, T. Fan, Y. Feng, Y. Huang, J. Fu and T. Wang, Org. Biomol. Chem., 2018, 16, 3099
    DOI: 10.1039/C8OB00488A

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