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Issue 16, 2018
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Ene cyclization reaction in heterocycle synthesis

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Abstract

The ene cyclization has evolved to become an indispensable tool for the synthesis of various ring size heterocyclic compounds. In the past and recent years, many exciting reports have demonstrated the broad scope and synthetic utility of ene cyclization and the versatility of oxonium ion, iminium ion and thionium ion intermediates. Moreover, the ease of regio- and stereoselectivity of ene cyclization has led to the development of new types of heterocyclic compounds. This article aims at reviewing the utilities of ene cyclization reactions for the synthesis of various ring sizes of oxygen, nitrogen and sulfur heterocycles. It also covers some applications in natural product synthesis. The mechanism of the reactions is discussed wherever necessary. The review article covers the time period from 1986 to 2017.

Graphical abstract: Ene cyclization reaction in heterocycle synthesis

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Publication details

The article was received on 19 Feb 2018, accepted on 20 Mar 2018 and first published on 20 Mar 2018


Article type: Review Article
DOI: 10.1039/C8OB00429C
Citation: Org. Biomol. Chem., 2018,16, 2820-2840
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    Ene cyclization reaction in heterocycle synthesis

    P. Saha and A. K. Saikia, Org. Biomol. Chem., 2018, 16, 2820
    DOI: 10.1039/C8OB00429C

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