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Darzens reaction of thioisatins and sulfonium salts: approach to synthesis of thiochromenone derivatives with anticancer potency

Abstract

A new Darzens reaction of thioisatins and sulfonium salts has, for the first time, been reported. This reaction allows an efficient access to thiochromenone derivatives in good to excellent yields under mild reaction conditions. The substrate scope includes both electron-withdrawing and electron-donating groups on both the thioisatins and sulfonium salts. Moreover, some of synthesized thiochromenone derivatives have been found to show potent anticancer activities against six different cancer cell lines using the methylthiazoltetrazolium (MTT) assay.

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Publication details

The article was received on 15 Feb 2018, accepted on 16 Apr 2018 and first published on 16 Apr 2018


Article type: Paper
DOI: 10.1039/C8OB00402A
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Darzens reaction of thioisatins and sulfonium salts: approach to synthesis of thiochromenone derivatives with anticancer potency

    J. Shen, Y. Yang, X. Hou, W. Zeng, A. Yu, X. Zhao and X. Meng, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB00402A

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