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Metal-free iodine(III)-promoted synthesis of 2,5-diaryloxazoles

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Abstract

A nonmetal-catalyzed oxidative cyclization to achieve 2,5-disubstituted oxazoles from inexpensive and readily available substituted chalcone, (diacetoxyiodo)benzene (PIDA) and ammonium acetate (NH4OAc) at room temperature is described. The reaction forms a variety of 2,5-diaryloxazoles in good to excellent yields with broad substrate scope under mild conditions without the requirement of ligands and additional bases.

Graphical abstract: Metal-free iodine(iii)-promoted synthesis of 2,5-diaryloxazoles

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Publication details

The article was received on 14 Feb 2018, accepted on 28 Mar 2018 and first published on 29 Mar 2018


Article type: Communication
DOI: 10.1039/C8OB00401C
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Metal-free iodine(III)-promoted synthesis of 2,5-diaryloxazoles

    X. Yang, X. Guo, M. Qin, X. Yuan, H. Jing and B. Chen, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00401C

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