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Issue 22, 2018
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Synthetic studies toward the marine metabolite prorocentin-4: synthesis of the C1–C23 fragment

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Abstract

A synthetic study of the construction of the C1–C23 fragment of prorocentin-4, a novel linear polyketide, is described. The synthetic highlights include the acid catalyzed epoxide opening, Gilman reaction, Pd(OH)2 catalyzed transformation of a primary propargylic alcohol into an aldehyde, Oxa-Michael cyclization, and Horner–Wadsworth–Emmons (HWE) olefination reaction as key steps.

Graphical abstract: Synthetic studies toward the marine metabolite prorocentin-4: synthesis of the C1–C23 fragment

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Publication details

The article was received on 14 Feb 2018, accepted on 24 Apr 2018 and first published on 10 May 2018


Article type: Paper
DOI: 10.1039/C8OB00388B
Citation: Org. Biomol. Chem., 2018,16, 4191-4194
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    Synthetic studies toward the marine metabolite prorocentin-4: synthesis of the C1–C23 fragment

    P. AnkiReddy, S. AnkiReddy and S. Gowravaram, Org. Biomol. Chem., 2018, 16, 4191
    DOI: 10.1039/C8OB00388B

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