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Dynamic kinetic resolution of biaryl atropisomers by chiral dialkylaminopyridine catalysts

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Abstract

The acylative dynamic kinetic resolution (DKR) of configurationally unstable biaryl atropisomers is achieved by using newly developed chiral dialkylaminopyridine catalysts with fluxional chirality. Various types of biaryl substrates containing phenolic structures were subjected to the DKR to obtain a range of acylated biaryl products with enantiomeric ratios up to 90 : 10.

Graphical abstract: Dynamic kinetic resolution of biaryl atropisomers by chiral dialkylaminopyridine catalysts

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Publication details

The article was received on 13 Feb 2018, accepted on 14 Mar 2018 and first published on 14 Mar 2018


Article type: Paper
DOI: 10.1039/C8OB00384J
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Dynamic kinetic resolution of biaryl atropisomers by chiral dialkylaminopyridine catalysts

    G. Ma, C. Deng, J. Deng and M. P. Sibi, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00384J

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