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Issue 15, 2018
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Persulfate-promoted oxidative C–N bond coupling of quinoxalinones and NH-sulfoximines

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Abstract

The persulfate-meditated oxidative C–N bond coupling of the C–H bond of quinoxalinones and the N–H bond of NH-sulfoximines is reported. The reaction proceeds smoothly under transition metal-free conditions and provides good to excellent yields of sulfoximidoyl-functionalized quinoxalinone products under mild conditions. The optimized conditions were found to be suitable for a range of sulfoximine and quinoxalinone substrates. This reaction offers a new and convenient strategy to directly install the sulfoximine moiety into the C3 position of quinoxalinone.

Graphical abstract: Persulfate-promoted oxidative C–N bond coupling of quinoxalinones and NH-sulfoximines

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Publication details

The article was received on 12 Feb 2018, accepted on 17 Mar 2018 and first published on 19 Mar 2018


Article type: Paper
DOI: 10.1039/C8OB00375K
Citation: Org. Biomol. Chem., 2018,16, 2697-2704
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    Persulfate-promoted oxidative C–N bond coupling of quinoxalinones and NH-sulfoximines

    L. Sumunnee, C. Pimpasri, M. Noikham and S. Yotphan, Org. Biomol. Chem., 2018, 16, 2697
    DOI: 10.1039/C8OB00375K

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