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Copper nitrate: A privileged reagent for organic synthesis


Copper has been explored as an ideal candidate to replace noble metals in organic synthesis, especially for practical large scale preparation. Recent decades have witnessed the renaissance and improvement of copper-catalyzed and copper-mediated organic reactions. Copper nitrate is a common inorganic copper salt, which has been proven to be a ubiquitous reactant in organic synthesis due to its commercial availability, stability, inexpensiveness and environmental-benign nature. Copper nitrate could be used as the nitration reagent, oxidant, catalyst or promoter, and Lewis acid as well. Remarkably, great attention has been attracted on efficient application of copper nitrate into functionalized or complicated compounds through various reaction types including cyclization, C–H activation, difunctionalization, nitration, rearrangement and asymmetric synthesis with chiral ligands. Further modification of copper nitrate, such as solid-supported copper nitrate or copper nitrate complexes, extends its applications in organic synthesis. The present review highlights the recent advances of copper nitrate in organic synthesis, along with their mechanisms.

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Publication details

The article was received on 08 Feb 2018, accepted on 12 Mar 2018 and first published on 14 Mar 2018

Article type: Review Article
DOI: 10.1039/C8OB00332G
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Copper nitrate: A privileged reagent for organic synthesis

    M. Gao, R. Ye, W. Shen and B. Xu, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB00332G

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