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Issue 13, 2018
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Synthesis and application of a new hexamethyl-1,1′-spirobiindane-based chiral bisphosphine (HMSI-PHOS) ligand in asymmetric allylic alkylation

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Abstract

The emerging and versatile application of chiral bisphosphine ligands in diverse asymmetric reactions has resulted in great demand for novel bisphosphine ligands containing different innovative backbones. Herein, a new type of chiral spiro bisphosphine ligand (HMSI-PHOS) has been developed on the basis of a hexamethyl-1,1′-spirobiindane motif. A series of new HMSI-PHOS ligands were synthesized and used in Pd-catalyzed asymmetric allylic alkylation reactions, and moderate to good yields and enantioselectivities were obtained with phenyl substituted ligands.

Graphical abstract: Synthesis and application of a new hexamethyl-1,1′-spirobiindane-based chiral bisphosphine (HMSI-PHOS) ligand in asymmetric allylic alkylation

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Publication details

The article was received on 02 Feb 2018, accepted on 06 Mar 2018 and first published on 07 Mar 2018


Article type: Paper
DOI: 10.1039/C8OB00279G
Citation: Org. Biomol. Chem., 2018,16, 2239-2247
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    Synthesis and application of a new hexamethyl-1,1′-spirobiindane-based chiral bisphosphine (HMSI-PHOS) ligand in asymmetric allylic alkylation

    S. Chang, L. Wang and X. Lin, Org. Biomol. Chem., 2018, 16, 2239
    DOI: 10.1039/C8OB00279G

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