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Copper-mediated regioselective hydrodifluoroalkylation of alkynes

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Abstract

A highly regioselective copper-mediated hydrodifluoroalkylation of alkynes with ethyl bromodifluoroacetate or bromodifluoroacetamides has been developed. This strategy provides straightforward access to a variety of difluoroalkylated alkenes under mild reaction conditions with low-cost cuprous bromide and metabisulfite as reduction agents. A wide range of alkynes are applicable under these reaction conditions. The excellent functional-group compatibility and good regio- and stereoselectivities are the notable features of this transformation.

Graphical abstract: Copper-mediated regioselective hydrodifluoroalkylation of alkynes

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Publication details

The article was received on 31 Jan 2018, accepted on 24 Mar 2018 and first published on 26 Mar 2018


Article type: Communication
DOI: 10.1039/C8OB00256H
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Copper-mediated regioselective hydrodifluoroalkylation of alkynes

    X. Feng, X. Wang, H. Chen, X. Tang, M. Guo, W. Zhao and G. Wang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00256H

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