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Issue 11, 2018
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Tandem radical cyclization for the construction of 1-difluoroalkylated isoquinolines via Cu catalyzed and visible light-promoted pathways

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Abstract

A Cu/B2pin2 system promoted cyclization for the synthesis of 1-difluoroalkylated isoquinolines with vinyl isocyanides and bromodifluoroacetic derivatives in moderate to good yields was reported. This method provided a mild and efficient pathway for the construction of diverse 1-difluoroalkylated isoquinolines via a proposed tandem radical cyclization process.

Graphical abstract: Tandem radical cyclization for the construction of 1-difluoroalkylated isoquinolines via Cu catalyzed and visible light-promoted pathways

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Publication details

The article was received on 27 Jan 2018, accepted on 12 Feb 2018 and first published on 12 Feb 2018


Article type: Communication
DOI: 10.1039/C8OB00232K
Citation: Org. Biomol. Chem., 2018,16, 1812-1815
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    Tandem radical cyclization for the construction of 1-difluoroalkylated isoquinolines via Cu catalyzed and visible light-promoted pathways

    F. Ding, Y. Jiang, K. Lin and L. Shi, Org. Biomol. Chem., 2018, 16, 1812
    DOI: 10.1039/C8OB00232K

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