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Issue 14, 2018
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Pd-catalyzed intramolecular C(sp2)–H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides

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Abstract

A palladium-catalyzed intramolecular C(sp2)–H amination of phenylalanine moieties in dipeptides is described. By this protocol, a series of indoline-2-carboxylate-containing dipeptides were synthesized from dipeptides. The N-protected amino acid moiety within the peptide is used as an intrinsic bidentate directing group. This intramolecular C–H amination reaction provides an appealing strategy for the post-synthetic modification of peptides.

Graphical abstract: Pd-catalyzed intramolecular C(sp2)–H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides

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Publication details

The article was received on 25 Jan 2018, accepted on 13 Mar 2018 and first published on 22 Mar 2018


Article type: Communication
DOI: 10.1039/C8OB00207J
Citation: Org. Biomol. Chem., 2018,16, 2402-2405
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    Pd-catalyzed intramolecular C(sp2)–H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides

    Y. Zheng, W. Song, Y. Zhu, B. Wei and L. Xuan, Org. Biomol. Chem., 2018, 16, 2402
    DOI: 10.1039/C8OB00207J

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