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Metal-free oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes leading to 3-acylated quinoxalin-2(1H)-ones

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Abstract

A facile TBHP-mediated direct oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes has been developed under metal-free conditions. This method provided a convenient and efficient approach to various 3-acylated quinoxalin-2(1H)-ones from readily available starting materials with excellent regioselectivity. This reaction proceeded efficiently under mild conditions over a broad range of substrates and with functional group tolerance.

Graphical abstract: Metal-free oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes leading to 3-acylated quinoxalin-2(1H)-ones

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Publication details

The article was received on 25 Jan 2018, accepted on 05 Apr 2018 and first published on 10 Apr 2018


Article type: Paper
DOI: 10.1039/C8OB00206A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Metal-free oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes leading to 3-acylated quinoxalin-2(1H)-ones

    J. Yuan, J. Fu, S. Liu, Y. Xiao, P. Mao and L. Qu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00206A

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