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Issue 15, 2018
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Accessing benzooxadiazepines via formal [4 + 3] cycloadditions of aza-o-quinone methides with nitrones

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Abstract

An unprecedented and efficient [4 + 3] cycloaddition of N-(ortho-chloromethyl)aryl amides with nitrones has been developed. This approach provides easy access to a series of seven-membered benzooxadiazepine derivatives in good to excellent yields (up to 99% yield) under mild reaction conditions.

Graphical abstract: Accessing benzooxadiazepines via formal [4 + 3] cycloadditions of aza-o-quinone methides with nitrones

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Publication details

The article was received on 24 Jan 2018, accepted on 22 Mar 2018 and first published on 23 Mar 2018


Article type: Communication
DOI: 10.1039/C8OB00201K
Citation: Org. Biomol. Chem., 2018,16, 2639-2642
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    Accessing benzooxadiazepines via formal [4 + 3] cycloadditions of aza-o-quinone methides with nitrones

    Y. Zheng, L. Tu, L. Gao, R. Huang, T. Feng, H. Sun, W. Wang, Z. Li and J. Liu, Org. Biomol. Chem., 2018, 16, 2639
    DOI: 10.1039/C8OB00201K

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