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Rhodium catalyzed C-H bond activation alkylation and cyclization of 2-arylquinazolin-4-ones

Abstract

An efficient method for the synthesis of isoquinolino [1,2-b] quinazolin-8-one derivatives and 12-methyl-12H-isoindolo [1,2-b] quinazoline-10-one derivatives is described herein. With rhodium catalysis, the desired products are obtained through a sequence reaction of C-H activation-based alkenylation and intramolecular aza-Heck-type cyclization. The developed method has a wide range of substrate tolerance under mild conditions and provides an alternative for structural elaboration of quinazoline compounds.

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Publication details

The article was received on 18 Jan 2018, accepted on 13 Feb 2018 and first published on 13 Feb 2018


Article type: Paper
DOI: 10.1039/C8OB00147B
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Rhodium catalyzed C-H bond activation alkylation and cyclization of 2-arylquinazolin-4-ones

    Y. Peng, M. Lou, Z. Deng, X. Mao, Y. Fu and Q. Yang, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB00147B

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