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Issue 11, 2018
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Rhodium-catalyzed C–H bond activation alkylation and cyclization of 2-arylquinazolin-4-ones

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Abstract

An efficient method for the synthesis of isoquinolino[1,2-b]quinazolin-8-one derivatives and 12-methyl-12H-isoindolo[1,2-b]quinazoline-10-one derivatives is described herein. With rhodium catalysis, the desired products are obtained through a sequence reaction of C–H activation-based alkenylation and intramolecular aza-Heck-type cyclization. The developed method has a wide range of substrate tolerance under mild conditions and provides an alternative for the structural elaboration of quinazoline compounds.

Graphical abstract: Rhodium-catalyzed C–H bond activation alkylation and cyclization of 2-arylquinazolin-4-ones

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Publication details

The article was received on 18 Jan 2018, accepted on 13 Feb 2018 and first published on 13 Feb 2018


Article type: Paper
DOI: 10.1039/C8OB00147B
Citation: Org. Biomol. Chem., 2018,16, 1851-1859
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    Rhodium-catalyzed C–H bond activation alkylation and cyclization of 2-arylquinazolin-4-ones

    M. Lou, Z. Deng, X. Mao, Y. Fu, Q. Yang and Y. Peng, Org. Biomol. Chem., 2018, 16, 1851
    DOI: 10.1039/C8OB00147B

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