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Issue 12, 2018
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The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses

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Abstract

The Curtius rearrangement is a versatile reaction in which a carboxylic acid can be converted to an isocyanate through an acyl azide intermediate under mild conditions. The resulting stable isocyanate can then be readily transformed into a variety of amines and amine derivatives including urethanes and ureas. There have been wide-ranging applications of the Curtius rearrangement in the synthesis of natural products and their derivatives. Also, this reaction has been extensively utilized in the synthesis and application of a variety of biomolecules. In this review, we present mechanistic studies, chemical methodologies and reagents for the synthesis of isocyanates from carboxylic acids, the conversion of isocyanates to amines and amine derivatives, and their applications in the synthesis of bioactive natural products and their congeners.

Graphical abstract: The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses

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Publication details

The article was received on 17 Jan 2018, accepted on 12 Feb 2018 and first published on 26 Feb 2018


Article type: Review Article
DOI: 10.1039/C8OB00138C
Citation: Org. Biomol. Chem., 2018,16, 2006-2027
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    The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses

    A. K. Ghosh, A. Sarkar and M. Brindisi, Org. Biomol. Chem., 2018, 16, 2006
    DOI: 10.1039/C8OB00138C

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