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Palladium-Catalyzed Dimerization of N-Aryl Propargylamines for the Synthesis of 3-Vinylquinolines

Abstract

A straightforward method for the synthesis of polyfunctionalized quinolines from readily available N-aryl propargylamines under aerobic condition is developed. It provides a convenient access to a variety of synthetically and pharmaceutically important quinolines in moderate to good yields. Control experiments suggest that the cascade reaction might proceed via the Pd-catalyzed electrophilic cyclization of N-aryl propargylamines followed by hydroarylation process through trapping of the σ-quinolinylpalladium intermediate with a second molecule of substrate.

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Publication details

The article was received on 17 Jan 2018, accepted on 05 Feb 2018 and first published on 05 Feb 2018


Article type: Paper
DOI: 10.1039/C8OB00133B
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Palladium-Catalyzed Dimerization of N-Aryl Propargylamines for the Synthesis of 3-Vinylquinolines

    X. Li, X. Zhang, B. Hu and X. zhang, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB00133B

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