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Issue 14, 2018
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Photocatalyzed cascade Meerwein addition/cyclization of N-benzylacrylamides toward azaspirocycles

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Abstract

A visible-light-induced cascade Meerwein addition/cyclization of alkenes involving C–F bond cleavage was developed. This method offers a rapid access to azaspirocyclic cyclohexadienones from N-benzylacrylamides via C–F bond cleavage applying H2O as an external oxygen source, allowing for the incorporation of various aromatic moieties originating from aryldiazonium salts.

Graphical abstract: Photocatalyzed cascade Meerwein addition/cyclization of N-benzylacrylamides toward azaspirocycles

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Publication details

The article was received on 17 Jan 2018, accepted on 10 Mar 2018 and first published on 17 Mar 2018


Article type: Communication
DOI: 10.1039/C8OB00132D
Citation: Org. Biomol. Chem., 2018,16, 2406-2410
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    Photocatalyzed cascade Meerwein addition/cyclization of N-benzylacrylamides toward azaspirocycles

    L. Yuan, S. Jiang, Z. Li, Y. Zhu, J. Yu, L. Li, M. Li, S. Tang and R. Sheng, Org. Biomol. Chem., 2018, 16, 2406
    DOI: 10.1039/C8OB00132D

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