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Copper(II)-mediated, carbon degradation-based amidation of phenylacetic acids toward N-substituted benzamides

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Abstract

The unprecedented synthesis of N-aryl substituted benzamides via the assembly of primary amines and phenylacetic acids has been developed in the presence of copper(II) acetate. This tandem transformation involving carbon–carbon bond cleavage provides a complementary tool with particular application in the synthesis of secondary benzamides.

Graphical abstract: Copper(ii)-mediated, carbon degradation-based amidation of phenylacetic acids toward N-substituted benzamides

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Publication details

The article was received on 09 Jan 2018, accepted on 02 Feb 2018 and first published on 02 Feb 2018


Article type: Paper
DOI: 10.1039/C8OB00064F
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Copper(II)-mediated, carbon degradation-based amidation of phenylacetic acids toward N-substituted benzamides

    L. Deng, B. Huang and Y. Liu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00064F

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