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Issue 13, 2018
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C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

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Abstract

Base modifications are known to affect the structure and function of DNA. C8-guanine adducts from various carcinogenic compounds have been shown to be potent Z-DNA inducers. Hence, it has been hypothesized that Z-DNA plays a role in cancer and other genetic diseases. In this comprehensive review, Z-DNA and the effect of prevalent C8-guanine adducts on the B–Z transition are addressed. The discoveries of Z-DNA binding proteins including ADAR1, E3L, DLM1, and PKZ have suggested the relevance of Z-DNA in living systems. In addition, increasing evidence on the Z-DNA connection to gene transcription and inhibition reveals potential biological functions of the left-handed DNA. Finally, C8-guanine adducts that promote Z-DNA formation can be used as a tool to explore the Z-DNA function and its role in carcinogenesis.

Graphical abstract: C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

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Publication details

The article was received on 04 Jan 2018, accepted on 28 Feb 2018 and first published on 02 Mar 2018


Article type: Review Article
DOI: 10.1039/C8OB00030A
Citation: Org. Biomol. Chem., 2018,16, 2198-2209
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    C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

    V. Vongsutilers and P. M. Gannett, Org. Biomol. Chem., 2018, 16, 2198
    DOI: 10.1039/C8OB00030A

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