Jump to main content
Jump to site search


An efficient synthesis of 16H-dibenzo[2,3:6,7][1,4]oxazepino[5,4-b]quinazolin-16-ones via an Ullmann reaction catalyzed by CuI

Author affiliations

Abstract

CuI functions as a mild Lewis acid catalyst to promote the condensation and cyclization reaction of 2-amino-N-(2-hydroxyphenyl)benzamide and 2-bromobenzaldehyde to build the quinazoline moiety first. With the addition of Cs2CO3, it also can catalyse the subsequent intramolecular Ullmann type reaction to give 16H-dibenzo[2,3:6,7][1,4]oxazepino[5,4-b]quinazolin-16-ones in good yields.

Graphical abstract: An efficient synthesis of 16H-dibenzo[2,3:6,7][1,4]oxazepino[5,4-b]quinazolin-16-ones via an Ullmann reaction catalyzed by CuI

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Jan 2018, accepted on 07 Feb 2018 and first published on 07 Feb 2018


Article type: Paper
DOI: 10.1039/C8OB00005K
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    An efficient synthesis of 16H-dibenzo[2,3:6,7][1,4]oxazepino[5,4-b]quinazolin-16-ones via an Ullmann reaction catalyzed by CuI

    Y. Zhang, J. Liu and X. Wang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00005K

Search articles by author

Spotlight

Advertisements