Issue 14, 2018
From the journal:

Organic & Biomolecular Chemistry

Ru(ii)-Catalyzed spirocyclization of aryl N-sulfonyl ketimines with aryl isocyanates through an aromatic C–H bond activation†

Nagarjuna Reddy K., ORCID logo ac   Subhadra U.,a   Sridhar B.b  and  Subba Reddy B. V. ORCID logo *a  

* Corresponding authors

a Centre for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad – 500 007, India
E-mail: basireddy@iict.res.in
Web: http://www.iictindia.org

b Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad – 500 007, India

c Academy of Scientific and Innovative Research (AcSIR), New Delhi – 110025, India

Abstract

A novel one-pot strategy has been developed for the construction of spiro-isoindolinone-benzosultams through a Ru(II)-catalyzed sequential C–C and C–N bond formation. This method is highly atom-economical and compatible with a wide range of substituents. This is the first report on the spirocyclization of 3-aryl N-sulfonyl ketimines with aryl isocyanates to produce highly rigid and pharmaceutically relevant spirocycles through a C–H bond activation.

Graphical abstract: Ru(ii)-Catalyzed spirocyclization of aryl N-sulfonyl ketimines with aryl isocyanates through an aromatic C–H bond activation

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Article information

DOI
https://doi.org/10.1039/C7OB03198J
Article type
Paper
Submitted
29 Dec 2017
Accepted
13 Mar 2018
First published
13 Mar 2018

Org. Biomol. Chem., 2018,16, 2522-2526

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Ru(II)-Catalyzed spirocyclization of aryl N-sulfonyl ketimines with aryl isocyanates through an aromatic C–H bond activation

N. R. K., S. U., S. B. and S. R. B. V., Org. Biomol. Chem., 2018, 16, 2522 DOI: 10.1039/C7OB03198J

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