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Issue 14, 2018
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Ru(II)-Catalyzed spirocyclization of aryl N-sulfonyl ketimines with aryl isocyanates through an aromatic C–H bond activation

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Abstract

A novel one-pot strategy has been developed for the construction of spiro-isoindolinone-benzosultams through a Ru(II)-catalyzed sequential C–C and C–N bond formation. This method is highly atom-economical and compatible with a wide range of substituents. This is the first report on the spirocyclization of 3-aryl N-sulfonyl ketimines with aryl isocyanates to produce highly rigid and pharmaceutically relevant spirocycles through a C–H bond activation.

Graphical abstract: Ru(ii)-Catalyzed spirocyclization of aryl N-sulfonyl ketimines with aryl isocyanates through an aromatic C–H bond activation

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Publication details

The article was received on 29 Dec 2017, accepted on 13 Mar 2018 and first published on 13 Mar 2018


Article type: Paper
DOI: 10.1039/C7OB03198J
Citation: Org. Biomol. Chem., 2018,16, 2522-2526
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    Ru(II)-Catalyzed spirocyclization of aryl N-sulfonyl ketimines with aryl isocyanates through an aromatic C–H bond activation

    N. R. K., S. U., S. B. and S. R. B. V., Org. Biomol. Chem., 2018, 16, 2522
    DOI: 10.1039/C7OB03198J

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