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A catalyst-free intermolecular trans-iodoalkylation of alkynes

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Abstract

We report the first catalyst-free and trans-selective iodoalkylation reaction of alkynes with a series of α-carbonyl compounds. This unprecedented three-component iodoalkylation reaction is enabled by using (iodoethynyl)trimethylsilane as a radical initiator and iodide source. The 1,2-difunctionalization affords alkenyl iodides, which are versatile building blocks for the construction of tri-substituted alkene derivatives.

Graphical abstract: A catalyst-free intermolecular trans-iodoalkylation of alkynes

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Publication details

The article was received on 21 Dec 2017, accepted on 10 Jan 2018 and first published on 11 Jan 2018


Article type: Communication
DOI: 10.1039/C7OB03159A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    A catalyst-free intermolecular trans-iodoalkylation of alkynes

    J. Liu, H. Huang, L. Cheng, Q. Liu, D. Wang and L. Liu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB03159A

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