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Issue 8, 2018
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Methods for the synthesis of annulated pyrroles via cyclisation strategies

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Abstract

Pyrrole, pyrrolidine, and indolizidine alkaloids represent important classes of natural products. Historically, these heterocycles and their derivatives have been the focus of significant interest in organic synthesis. In this report, we review the methods that have been employed to synthesise annulated pyrroles via transformations that include: Friedel–Crafts acylations and alkylations, Michael additions, Heck couplings, hydroarylations, carbenoid insertions, and radical cyclisations.

Graphical abstract: Methods for the synthesis of annulated pyrroles via cyclisation strategies

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Publication details

The article was received on 20 Dec 2017, accepted on 21 Jan 2018 and first published on 01 Feb 2018


Article type: Review Article
DOI: 10.1039/C7OB03144K
Citation: Org. Biomol. Chem., 2018,16, 1216-1226
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    Methods for the synthesis of annulated pyrroles via cyclisation strategies

    W. J. Olivier, J. A. Smith and A. C. Bissember, Org. Biomol. Chem., 2018, 16, 1216
    DOI: 10.1039/C7OB03144K

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