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Issue 10, 2018
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Panning for gold in mould: can we increase the odds for fungal genome mining?

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Abstract

Fungi are a rich source of bioactive small molecules. However, the large number of biosynthetic gene clusters (BGCs) encoding these molecules in their genomes suggests their biosynthetic potential is far greater than we previously appreciated. The mining of fungal genomes therefore holds great promise for the discovery of new chemical entities for pharmaceutical and agricultural applications. As more and more fungal genomes become available, the accompanying number of BGCs is quickly becoming unmanageable. Along with improving molecular genetic tools to accelerate the translation of BGCs to small molecules, we must devise strategies to prioritise BGCs most likely to encode the biosynthesis of novel small molecules and molecules with new or improved bioactivities or functions. In this perspective, we discuss existing and emerging strategies for prioritisation of BGCs to increase the odds of fruitful genome mining in fungi.

Graphical abstract: Panning for gold in mould: can we increase the odds for fungal genome mining?

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Publication details

The article was received on 18 Dec 2017, accepted on 27 Jan 2018 and first published on 29 Jan 2018


Article type: Perspective
DOI: 10.1039/C7OB03127K
Citation: Org. Biomol. Chem., 2018,16, 1620-1626
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    Panning for gold in mould: can we increase the odds for fungal genome mining?

    C. L. M. Gilchrist, H. Li and Y. Chooi, Org. Biomol. Chem., 2018, 16, 1620
    DOI: 10.1039/C7OB03127K

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