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Issue 8, 2018
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Ce(III)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

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Abstract

An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.

Graphical abstract: Ce(iii)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

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Publication details

The article was received on 16 Dec 2017, accepted on 21 Jan 2018 and first published on 22 Jan 2018


Article type: Communication
DOI: 10.1039/C7OB03113K
Citation: Org. Biomol. Chem., 2018,16, 1247-1251
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    Ce(III)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

    Z. Chen, X. Wen, Y. Qian, P. Liang, B. Liu and M. Ye, Org. Biomol. Chem., 2018, 16, 1247
    DOI: 10.1039/C7OB03113K

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