Issue 8, 2018

Ce(iii)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

Abstract

An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.

Graphical abstract: Ce(iii)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

Supplementary files

Article information

Article type
Communication
Submitted
16 Dec 2017
Accepted
21 Jan 2018
First published
22 Jan 2018

Org. Biomol. Chem., 2018,16, 1247-1251

Ce(III)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

Z. Chen, X. Wen, Y. Qian, P. Liang, B. Liu and M. Ye, Org. Biomol. Chem., 2018, 16, 1247 DOI: 10.1039/C7OB03113K

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