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Issue 12, 2018
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One-pot synthesis of diverse N,N′-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines

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Abstract

A sequential one-pot approach towards N,N′-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines is reported. This strategy provides straightforward and efficient access to diverse guanidines in yields up to 81% through previously unprecedented N-phthaloylguanidines. This protocol also features wide substrate scope and mild conditions.

Graphical abstract: One-pot synthesis of diverse N,N′-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines

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Publication details

The article was received on 15 Dec 2017, accepted on 01 Mar 2018 and first published on 08 Mar 2018


Article type: Paper
DOI: 10.1039/C7OB03109B
Citation: Org. Biomol. Chem., 2018,16, 2143-2149
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    One-pot synthesis of diverse N,N′-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines

    A. Demjén, A. Angyal, J. Wölfling, L. G. Puskás and I. Kanizsai, Org. Biomol. Chem., 2018, 16, 2143
    DOI: 10.1039/C7OB03109B

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