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O-Difluorodeuteromethylation of phenols using difluorocarbene precursors and deuterium oxide

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Abstract

The first O-difluorodeuteromethylation of phenols using commercial diethyl bromodifluoromethylphosphonate and deuterium oxide to prepare various difluorodeuteromethyl aryl ethers is reported. This facile method affords a convenient way to introduce OCF2D groups into organic molecules.

Graphical abstract: O-Difluorodeuteromethylation of phenols using difluorocarbene precursors and deuterium oxide

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Publication details

The article was received on 13 Dec 2017, accepted on 08 Feb 2018 and first published on 08 Feb 2018


Article type: Communication
DOI: 10.1039/C7OB03088F
Citation: Org. Biomol. Chem., 2018, Advance Article
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    O-Difluorodeuteromethylation of phenols using difluorocarbene precursors and deuterium oxide

    Y. Geng, M. Zhu, A. Liang, C. Niu, J. Li, D. Zou, Y. Wu and Y. Wu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB03088F

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