Issue 8, 2018

Oxalic/malonic acids as carbon building blocks for benzazole, quinazoline and quinazolinone synthesis

Abstract

An oxidant, base and metal free methodology has been developed for the synthesis of various 2-substituted and non-substituted benzazoles, quinazolines and quinazolinones using oxalic/malonic acids as an in situ carbon source. This methodology is applicable for a wide range of substituted o-phenylenediamine, o-aminothiophenol, o-aminophenol and o-aminobenzamide containing various functional groups and provides good to excellent yields of the corresponding product. Furthermore an easy workup procedure, high yield and easy isolation of products are key features of this methodology. The developed protocol is also applicable for the gram scale synthesis of benzimidazoles.

Graphical abstract: Oxalic/malonic acids as carbon building blocks for benzazole, quinazoline and quinazolinone synthesis

Supplementary files

Article information

Article type
Paper
Submitted
11 Dec 2017
Accepted
25 Jan 2018
First published
25 Jan 2018

Org. Biomol. Chem., 2018,16, 1337-1342

Oxalic/malonic acids as carbon building blocks for benzazole, quinazoline and quinazolinone synthesis

S. Sharma, D. Bhattacherjee and P. Das, Org. Biomol. Chem., 2018, 16, 1337 DOI: 10.1039/C7OB03064A

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