Jump to main content
Jump to site search

Issue 8, 2018
Previous Article Next Article

Oxalic/malonic acids as carbon building blocks for benzazole, quinazoline and quinazolinone synthesis

Author affiliations

Abstract

An oxidant, base and metal free methodology has been developed for the synthesis of various 2-substituted and non-substituted benzazoles, quinazolines and quinazolinones using oxalic/malonic acids as an in situ carbon source. This methodology is applicable for a wide range of substituted o-phenylenediamine, o-aminothiophenol, o-aminophenol and o-aminobenzamide containing various functional groups and provides good to excellent yields of the corresponding product. Furthermore an easy workup procedure, high yield and easy isolation of products are key features of this methodology. The developed protocol is also applicable for the gram scale synthesis of benzimidazoles.

Graphical abstract: Oxalic/malonic acids as carbon building blocks for benzazole, quinazoline and quinazolinone synthesis

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Dec 2017, accepted on 25 Jan 2018 and first published on 25 Jan 2018


Article type: Paper
DOI: 10.1039/C7OB03064A
Citation: Org. Biomol. Chem., 2018,16, 1337-1342
  •   Request permissions

    Oxalic/malonic acids as carbon building blocks for benzazole, quinazoline and quinazolinone synthesis

    S. Sharma, D. Bhattacherjee and P. Das, Org. Biomol. Chem., 2018, 16, 1337
    DOI: 10.1039/C7OB03064A

Search articles by author

Spotlight

Advertisements