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Issue 11, 2018
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C5-Regioselective C–H fluorination of 8-aminoquinoline amides and sulfonamides with Selectfluor under metal-free conditions

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Abstract

A novel and efficient regioselective C–H fluorination of 8-aminoquinoline amides and sulfonamides at the C5 position was achieved. Using Selectfluor as a “F” reagent and HOAc as an additive, the reaction proceeds smoothly via a radical pathway. This method features metal-free conditions, a broad substrate scope and operational simplicity.

Graphical abstract: C5-Regioselective C–H fluorination of 8-aminoquinoline amides and sulfonamides with Selectfluor under metal-free conditions

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Publication details

The article was received on 11 Dec 2017, accepted on 29 Jan 2018 and first published on 29 Jan 2018


Article type: Paper
DOI: 10.1039/C7OB03059B
Citation: Org. Biomol. Chem., 2018,16, 1912-1920
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    C5-Regioselective C–H fluorination of 8-aminoquinoline amides and sulfonamides with Selectfluor under metal-free conditions

    Y. Zhang, C. Wen and J. Li, Org. Biomol. Chem., 2018, 16, 1912
    DOI: 10.1039/C7OB03059B

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