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C5-regioselective C-H fluorination of 8-aminoquinoline amides and sulfonamides with selectfluor under metal-free conditions

Abstract

A novel and efficient regioselective C-H fluorination of 8-aminoquinoline amides and sulfonamides at C5 position was achieved. Using selectfluor as “F” reagent and HOAc as additive, the reaction proceeds smoothly via radical pathway. This method features metal-free conditions, broad substrate scope and operational simplicity.

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Publication details

The article was received on 11 Dec 2017, accepted on 29 Jan 2018 and first published on 29 Jan 2018


Article type: Paper
DOI: 10.1039/C7OB03059B
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    C5-regioselective C-H fluorination of 8-aminoquinoline amides and sulfonamides with selectfluor under metal-free conditions

    Y. Zhang, C. Wen and J. Li, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7OB03059B

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