Catalytic synthesis of 3-aminooxindoles via addition to isatin imine: an update

Abstract

3-Substituted-3-aminooxindoles have attracted the attention of organic chemists since they have a common core structural motif found in many natural products and biologically active compounds. During the past six years, the new synthetic methodologies for the synthesis of this moiety have shown rapid growth. Thus, an update of our previous review has become necessary and this review includes the literature on this topic, covering the reactions of isatin imine explored in various organic transformations catalyzed by metals and organocatalysts.