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Norcrassin A, one novel C16 tetranorditerpenoid, and bicrotonol A, one unusual dimeric labdane-type diterpenoid from the roots of Croton crassifolius

Abstract

One novel C16 tetranorditerpenoid, norcrassin A (1), and one unusual dimeric labdane-type diterpenoid, bicrotonol A (2), were isolated from the roots of Croton crassifolius. Norcrassin A (1) featured a new carbon skeleton with an unprecedented 5/5/5/6 tetracyclic system. Bicrotonol A (2) possessed an unusual tetrahydroxypyran ring linkage connecting two labdane diterpenoid monomers. The structures of all compounds, including the absolute configuration, were elucidated by interpretation of their NMR spectroscopic data, high resolution mass spectrometry, and single-crystal X-ray diffraction. The plausible biosynthetic pathway of 1 is proposed. The anti-Alzheimer Disease (AD) activities of 1 and 2 are also evaluated using the AD pathological model.

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Publication details

The article was received on 04 Dec 2017, accepted on 13 Feb 2018 and first published on 13 Feb 2018


Article type: Paper
DOI: 10.1039/C7OB02991H
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Norcrassin A, one novel C16 tetranorditerpenoid, and bicrotonol A, one unusual dimeric labdane-type diterpenoid from the roots of Croton crassifolius

    Z. Zhang, P. Wu, H. Li, F. Qi, D. Fei, Q. Hu, Y. Liu and X. Huang, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7OB02991H

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