Jump to main content
Jump to site search

Issue 11, 2018
Previous Article Next Article

Catalyst-free synthesis of thiazolidines via sequential hydrolysis/rearrangement reactions of 5-arylidenethiazolidin-4-ones at room temperature

Author affiliations

Abstract

A catalyst-free sequential reaction involving hydrolysis and intramolecular aza-Michael addition was developed for synthesizing functionalized thiazolidines from 5-arylidenethiazolidin-4-ones at room temperature. A series of thiazolidine-5-carboxylic acids were prepared in good to excellent yields (up to 97% yield) and excellent diastereoselectivities (up to >20 : 1 dr). This methodology was applicable to the construction of derivatives of thiacloprid and flutianil with good yields.

Graphical abstract: Catalyst-free synthesis of thiazolidines via sequential hydrolysis/rearrangement reactions of 5-arylidenethiazolidin-4-ones at room temperature

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Nov 2017, accepted on 06 Feb 2018 and first published on 06 Feb 2018


Article type: Paper
DOI: 10.1039/C7OB02924A
Citation: Org. Biomol. Chem., 2018,16, 1932-1938
  •   Request permissions

    Catalyst-free synthesis of thiazolidines via sequential hydrolysis/rearrangement reactions of 5-arylidenethiazolidin-4-ones at room temperature

    F. Zeng, L. Zhang, X. Shao, Z. Li and X. Xu, Org. Biomol. Chem., 2018, 16, 1932
    DOI: 10.1039/C7OB02924A

Search articles by author

Spotlight

Advertisements