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Specific labeling of mitochondria of Chlamydomonas with cationic helicene fluorophores

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Abstract

Twelve cationic helicenes and one triangulene were tested for the specific labeling of mitochondria from algal cells. Octyl ester derivative 5 readily penetrates algal cells and gives rise to clear fluorescence patterns when it is used at concentrations in the μM range. Under these conditions, cell structures are well preserved and cell survival is not compromised. Cationic helicene compounds such as 5 provide new useful tools for examining the mitochondrial network and its dynamics including fission and fusion events.

Graphical abstract: Specific labeling of mitochondria of Chlamydomonas with cationic helicene fluorophores

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Publication details

The article was received on 24 Nov 2017, accepted on 09 Jan 2018 and first published on 09 Jan 2018


Article type: Paper
DOI: 10.1039/C7OB02906C
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Specific labeling of mitochondria of Chlamydomonas with cationic helicene fluorophores

    C. Bauer, R. Duwald, G. M. Labrador, S. Pascal, P. Moneva Lorente, J. Bosson, J. Lacour and J. Rochaix, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02906C

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