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A novel lysosome-targeted fluorogenic probe based on 5-triazole-quinoline for the rapid detection of hydrogen sulfide in living cells

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Abstract

A fluorogenic probe based on the novel fluorophore 5-triazole-quinoline was developed for the detection of hydrogen sulfide, an endogenous signaling molecule associated with the development of various diseases. The lysosome-targeted probe Lyso-HS was synthesized via C–H direct azidation from 8-aminoquinoline; it was able to detect H2S in 1 min and exhibited excellent turn-on ability with 95-fold fluorescence enhancement based on a new fluorochrome. The high quenching efficiency was further verified using time-dependent density functional theory (TDDFT). The probe also exhibited high selectivity and a low detection limit (as low as 214.5 nM), which has practical applications for disease detection and monitoring.

Graphical abstract: A novel lysosome-targeted fluorogenic probe based on 5-triazole-quinoline for the rapid detection of hydrogen sulfide in living cells

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Publication details

The article was received on 22 Nov 2017, accepted on 09 Jan 2018 and first published on 09 Jan 2018


Article type: Communication
DOI: 10.1039/C7OB02881D
Citation: Org. Biomol. Chem., 2018, Advance Article
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    A novel lysosome-targeted fluorogenic probe based on 5-triazole-quinoline for the rapid detection of hydrogen sulfide in living cells

    Y. Dou, X. Gu, S. Ying, S. Zhu, S. Yu, W. Shen and Q. Zhu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02881D

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