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Can strand displacement take place in DNA triplexes?

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Abstract

This work studies strand displacement in the context of DNA triplexes. We observed that toehold-mediated strand displacement could proceed in DNA triplexes, but at a much slower rate than in DNA duplexes. In this study, strand displacement was studied with native polyacrylamide gel electrophoresis (PAGE) for two molecular systems. While both systems were involved in branch migration in a DNA triplex, the toehold forms either a duplex or a triplex. This study provides a new strategy for sequence-specific strand displacement and it is useful for the construction of dynamic DNA nanostructures and control of smart DNA nanodevices.

Graphical abstract: Can strand displacement take place in DNA triplexes?

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Publication details

The article was received on 21 Nov 2017, accepted on 11 Dec 2017 and first published on 21 Dec 2017


Article type: Communication
DOI: 10.1039/C7OB02871G
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Can strand displacement take place in DNA triplexes?

    Q. Li, C. Tian, X. Li and C. Mao, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02871G

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