Jump to main content
Jump to site search


DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides

Author affiliations

Abstract

A highly efficient protocol for a direct thiolation of N-substituted pyrazolones with diaryl disulfides is described. Using a combination of DABCO and silver(I) acetate, the C–S bond formation proceeds smoothly at room temperature under mild and easy to handle conditions. This synthetic strategy offers a convenient and direct modification of antipyrine and other pyrazolone substrates, giving a series of aryl sulfide-substituted pyrazolone products in moderate to excellent yields.

Graphical abstract: DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Nov 2017, accepted on 12 Dec 2017 and first published on 12 Dec 2017


Article type: Paper
DOI: 10.1039/C7OB02860A
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides

    A. Thupyai, C. Pimpasri and S. Yotphan, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02860A

Search articles by author

Spotlight

Advertisements