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Issue 9, 2018
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Mannich reaction of trifluoroacetaldehyde hydrazones: a useful entry to trifluoromethyl substituted heterocycles

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Abstract

NH-aryl hydrazones derived from trifluoroacetaldehyde hemiacetal may be involved in efficient Mannich type reactions with formaldehydes and aromatic aldehydes. The resulting hydrazones are useful building blocks for the preparation of trifluoromethyl substituted heterocycles as shown by a straightforward preparation of 1,2-diazine derivatives under heating with β-ketoesters.

Graphical abstract: Mannich reaction of trifluoroacetaldehyde hydrazones: a useful entry to trifluoromethyl substituted heterocycles

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Publication details

The article was received on 19 Nov 2017, accepted on 31 Jan 2018 and first published on 31 Jan 2018


Article type: Communication
DOI: 10.1039/C7OB02840G
Citation: Org. Biomol. Chem., 2018,16, 1457-1460
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    Mannich reaction of trifluoroacetaldehyde hydrazones: a useful entry to trifluoromethyl substituted heterocycles

    S. Jia and L. El Kaim, Org. Biomol. Chem., 2018, 16, 1457
    DOI: 10.1039/C7OB02840G

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